PRIAM is a program that searches for enzymes in a fully sequenced genome. The search is based on all sequences available in the ENZYME database.

PRIAM relies on sets of position-specific score matches (PSSMs) automatically tailored for each ENZYME entry.

References:
Clotilde Claudel-Renard, Claude Chavalet, Thomas Faraut and Daniel Kahn Enzyme-specific profiles for genome annotation: PRIAM Nucleic Acids Research, 2003, Vol. 31, No. 22 6633-6639 Entrez